Lin Tianwei
Lin Tianwei
Lin Tianwei, male, doctor, Professor, School of life sciences, Xiamen University.
Research direction
Structure and molecular biology of hand foot mouth disease
Interaction between virus and host innate immune system
Structural biology of nuclear receptors
Structure based chemical drug development
Structure based macromolecular drug development
Application of viral structure in nano chemistry, materials science and medicine
Character experience
1979-1983, Bachelor of science, Department of biology, Xiamen University
1983-1984, assistant professor, Department of biology, Xiamen University
1985-1992, Department of Biochemistry, University of Alberta, Canada
1991-1995, postdoctoral, Department of Biological Sciences, Purdue University, USA
1995-2000, senior researcher, Department of molecular biology, Scripps Institute, USA
2000-2005, assistant professor, Department of molecular biology, Scripps Institute and Joint Center for Molecular Life Sciences, USA
2004-2007, adjunct professor, Institute of Biophysics, Chinese Academy of Sciences
Visiting professor, Xiamen University, 2004-2007
2005-2006, associate professor of molecular biology department and joint Molecular Life Science Center of Scripps Institute, 2006-2007, part-time associate professor of molecular biology department and joint Molecular Life Science Center of Scripps Institute, USA
Visiting professor, Department of Microbiology, University of Hong Kong, 2006-2008
2008-2010, honorary associate professor, Department of Microbiology, University of Hong Kong
Since 2007, Professor of life sciences, Xiamen University
academic achievements
one
LinTW.
,andJohnson,J.E.(2003).StructuresofPicorna-likepla ntviruses:implicationsandapplications.
Adv.VirusRes
.62,167-239.
two
LinTW.
(2006).StructuralandMolecularGenesisoftheChemicalAddressabilityofaViralNanoblock.
J. Mat.Chem .
16,3673-3681.
three
LinTW*.
,WangGY.,LiAZ.,ZhangQ.,WuCM.,ZhangRF.,CaiQX.,SongWJ.,YuenKY.(2009).ThehemagglutininstructureofanH1N1influenzaAvirus.
Virology.
392,73-81.
4.ZhanYY.#,ChenY.#,ZhangQ.#,ZhuangJJ.,TianM.,ChenHZ.,ZhangLR,ZhangHK.,HeJP.,WangWJ.,WuR.,WangY.,ShiC.,YangK.,LiAZ.,XinYZ.,LiTY.,YangJY.,ZhengZH.,YuCD.,LinSC.,ChangCS.,HuangPQ.,
LinTW*
,WuQ.*(2012).TheorphannuclearreceptorNur77regulatesLKB1localizationandactivatesAMPK.
NatChemBiol
.8,897-904.
5.WuCM.#,CaiQX.#,ChenC.,LiN.,PengXJ.,CaiYX.,YinK.,ChenXS.,WangXL.,ZhangRF.,LiuLJ.,ChenSH.,LiJ*.,
LinTW.*.
(2013).CrystalStructuresofanEnterovirus713CProteinase( strain:E2004104-TW-CDC )andItsComplexwithRupintrivir.
ActaCryst.
D69,866–871.
6.CaiQX.#,YameenM.#,LiuWH.#,GaoZT.,LiYZ.,PengXJ.,CaiYX.,WuCM.,ZhengQ.,LiJ.*,
LinTW.*
(2013).ConformationalPlasticityof2AProteinasefromEnterovirus71.
J.Virol
.87,7348-7356.
7.WangWJ.#,WangY.#,ChenHZ.#,XingYZ.#,LiFW.#,ZhangQ.,ZhouB.,Zhang,HK.,ZhangJ.,BianXL.,LiL.,LiuY.,ZhaoBX.,ChenY.,WuR.,LiAZ.,YaoLM.,ChenP.,ZhangY.,TianXY.,BeermannF.,WuM.,HanJH.,HuangPQ.,
LinTW*
,WuQ.*.(2014).OrphannuclearreceptorTR3actsinautophagiccelldeathviamitochondrialsignalingpathway.
Nat.Chem.Biol .
10:133-140.
8.LiL#,LiuY#,ChenHZ#,LiFW#,WuJF,ZhangHK,HeJP,XingYZ,ChenY,WangWJ,TianXY,LiAZ,ZhangQ,HuangPQ,HanJH,
LinTW*
,WuQ*.(2015).Impedingtheinteractionbetweennur77andp38reducesLps-inducedinflammation.
Nat.Chem.Biol .
11:339–346.
9.KongC., SrinivasaR.Penumutchu ,Kuo-weiHung,HuangHY.,
LinTW*.
,YuC*.(2015).BackboneresonanceassignmentsofthePRYSPRYdomainofTRIM25.
BiomolNMRAssign.
9:313-315.
10.WangWJ#.,WangY.#,HouPP.#,LiFW.#,ZhouB,ChenHZ,BianXL,CaiQX,XingYZ,HeJP,ZhangHK,HuangPQ,
LinTW*
,WuQ*.(2015).InductionofAutophagicDeathinCancerCellsbyAgonizingTR3andAttenuatingAkt2Activity.
Chem.Biol .
22(8):1040-51.
11.WuCM#.,ZhangLJ#.,LiP#.,CaiQX#.,PengXJ.,YinK.,ChenXS.,RenHX.,ZhongSL.,WengYW.,GuanY.,ChenSH.,WuJZ.*,LiJ.*,
LinTW*
.(2016).Fragment-wisedesignofinhibitorsto3Cproteinasefromenterovirus71.
BiochimicaetBiophysicaActa-GeneralSubjects.
1860(6):1299-1307.
12.ZhangLJ#.,HuangGL#.,CaiQX#.,ZhaoC.,TangLY.,RenHX.,LiP.,LiN.,HuangJW.,ChenXQ.,GuanY.,YouH.,ChenSH.,LiJ*.,
LinTW*
.(2016).OptimizetheinteractionsatS4withefficientinhibitorstargeting3Cproteinasefromenterovirus71.
Lin Tianwei