You song

You song

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You song, male, born in 1963. Director of Department of biopharmaceutical, School of life science and biopharmaceutical, Shenyang Pharmaceutical University, Professor of Department of Microbiology and cell biology, doctoral supervisor.

Basic information

Name: You song

Major: Medicine - traditional Chinese Medicine

On the job: on the job

Gender: Male

Department: School of life sciences and Biopharmaceuticals

Educational background

He graduated from Shenyang Pharmaceutical University in 1985 with a master's degree in pharmaceutical chemistry from Shenyang Pharmaceutical University in 1989 and a doctor's degree in pharmaceutical chemistry from Shenyang Pharmaceutical University in 1998. During the two and a half years, he studied in the Pharmaceutical Department of Tokyo University, Japan, engaged in the research of natural product biosynthesis, and completed his doctoral thesis entitled "Research on steroidal saponin biosynthesis". In 2001, it was selected into Liaoning Province's ten million talent project.

Biography of characters

September 1981 - July 1985, Shenyang Pharmaceutical University, undergraduate study

August 1985 - August 1987 assistant professor of Shenyang Pharmaceutical College

From September 1987 to July 1989, master degree of Shenyang Pharmaceutical University was obtained in advance due to outstanding scientific research work

August 1989 - August 1995 assistant professor and lecturer of Shenyang Pharmaceutical University

September 1995 - June 1998: doctoral candidate of Shenyang Pharmaceutical University

From February 1996 to April 1998, he studied in the Pharmaceutical Department of Tokyo University, Japan, and completed his doctoral dissertation entitled "Research on genes related to steroidal saponin biosynthesis pathway"

From July 1998 to November 2000, associate professor, Department of biopharmaceutical, Shenyang Pharmaceutical University, tutor of master's degree

December 2000 -- Professor and doctoral supervisor, Department of Microbiology and cell biology, Shenyang Pharmaceutical University

Social Appointments

He is a senior member of the Chinese Pharmaceutical Association, a member of the professional committee of biochemical drugs, a member of the Liaoning Provincial Science and Technology Fund Evaluation Committee, a member of the Shenyang Municipal Committee of the Chinese people's Political Consultative Conference, chairman of the microbiology and biochemical pharmacy branch of the academic degree committee of Shenyang Pharmaceutical University, and an executive editorial board member of the Journal of Shenyang Pharmaceutical University.

Teaching experience

Since 1985, he has been a teaching assistant and lecturer in the teaching and research section of natural pharmaceutical chemistry, College of traditional Chinese medicine, and an associate professor and professor in the teaching and research section of biopharmaceutical, College of pharmaceutical engineering. He has successively undertaken the teaching of natural pharmaceutical chemistry, spectral analysis of organic compounds, professional English of traditional Chinese medicine, introduction to biopharmaceutical, pharmaceutical biotechnology, biocatalysis and professional English of biotechnology and related practical courses The experiment teaching. The discipline of biology and traditional Chinese medicine enrolls postgraduates, and now guides 18 master's postgraduates and 5 doctoral postgraduates. 13 graduate students and 3 doctoral students have been trained.

research field

Biology and pharmacy of natural products: biocatalysis based on active natural products and its application in drug research and development is to apply molecular biology technology and microbial fermentation technology to the research of "biosynthesis and biotransformation of active secondary metabolites".

1. Biocatalysis mainly involves various chemical reactions, such as hydroxylation, epoxidation, dehydrogenation, hydrogenation, hydrolysis, lipidization, dehydration, and so on. Some metabolites have very complex chemical reactions in the reaction process. We can find new derivatives with medicinal value through these reactions, and we can also find enzymes in microorganisms that make these reactions occur for industrial production. For example, camptothecin and hydroxycamptothecin are anticancer compounds in Camptotheca acuminata fruit. 10 hydroxycamptothecin has good curative effect and low toxicity, but its content is very low. Its resource problem can be successfully solved by biotransformation and biosynthesis.

2. Research on the development of natural drugs: natural drugs have long been a powerful weapon for the prevention and treatment of diseases. So far, many countries and regions in the world still use natural drugs as an important means of disease prevention and treatment. In addition to the research on the biosynthesis and biotransformation of natural drugs, our laboratory has made remarkable achievements in the development of natural drugs by taking advantage of our advantages in separation, purification and qualitative and quantitative analysis.

Scientific research conditions

It has the advanced hardware experimental conditions to carry out natural product chemistry, analytical chemistry, bioinformatics, microbiology and molecular biology, interdisciplinary research, such as five sets of HPLC (analytical and semi preparative), circular dichroism, and equipped with a variety of detectors, such as ultraviolet, evaporative light, fluorescence. There are two sets of desktop and floor type high-speed low-temperature centrifuges, one is gel imaging system, the other is cryogenic refrigerator, freeze-drying machine, and PCR, fermentor, electrophoresis apparatus and conventional chromatography separation system. In addition, it has laid a solid foundation for the collection, cultivation and utilization of microbial strains, natural enzymes and recombinant enzymes, as well as the accumulation of natural product samples and their separation, purification and analysis technologies, and is forming obvious competitiveness and influence in related fields.

Research achievements

Over the years, he has successively presided over one new drug fund project of the Ministry of science and technology of the people's Republic of China, one fund of the State Administration of traditional Chinese medicine, one fund for outstanding young teachers of the Ministry of education, one major provincial new drug project and two science and technology funds, undertaken a number of enterprise R & D projects, and applied for a number of national patents. It has successively won one first prize of science and technology progress award of Shenyang City, one third prize of science and technology progress award of State Food and drug administration, and has applied for many new drugs. In recent years, it has received more than 5 million yuan of funding from various aspects and the contract value is more than 10 million yuan. In 2006, Shenyang Pharmaceutical University "Tenth Five Year" scientific and technological achievements transformation award, in 2006, Shenyang Pharmaceutical University "Tenth Five Year" scientific research environment construction award.

publish one’s thesis

1.Wang,D.,YangL,GuanH,ChenY.-N,XuW.-Z.,YouS*.,StereoselectivehydrogenationontheexocyclicandconjugateddoublebondofsesquiterpenelactonesbyAspergillusversicolorD-1.JournalofAsianNaturalProductsResearch,2009.11(12):p.991-996.

2.Chen,Y.-n.,L.Wang,J.Ren,Y.Liu,You.S*,TheselectivebiotransformationoffurostanolglycosidesandtheiranalogsbyrecombinedF-26-O-β- glucosidase.AsianJournalofTraditionalMedicine ,2009.4(1):p.7-13.

3. You song *, you Kai, Wang Xu, Zhao Jing, Wang Dan, extraction, purification and biotransformation of resveratrol glucoside. Journal of Shenyang Pharmaceutical University, 2009 (04): p.312-315

4. Xu WeiLuo, Qin bin, Chen Yinan, Song Ming, you song *, application of biocatalysis in the preparation of chiral drugs. Chinese Journal of pharmaceutical chemistry, 2009 (06): p.420-428

5. Ma Jiapeng, Chen Yinan, Qin bin, Jia Xian, Guo Chun, you song *, detection method and spontaneous hydrolysis of DL pantolactone in enzymatic resolution. Journal of Shenyang Pharmaceutical University, 2009 (11): p.916-919 + 924

6.Guan,H.,YangL,GuoJ.,MaX.,WangH.,You.S*,MorphologicalandMolecularIdentifcationofAspergillusVersicolorD-1withSelec tiveReductionAbility.AsianJournalofTraditionalMedicine ,2007.2(1):p.1-6.

7.Fengqing,H.You.S*InactivationoftypeIpolyhydroxyalkanoatesynthaseinAeromonashydrophilaresultedindiscoveryofanother potentialPHAsynthase.JIndMicrobiolBiotechnol ,2007.34(3):p.255-60.

8.RenJ,L.Yan-qiu,YangL,RuiN,.YouS*,MolecularCloningandBacterialExpressionofGermacreneASynthasecDNAfromCrepi diastrumsonchifolium.ChemicalResearchinChineseUniversities ,2006.22(5):p.606-611.

9. Wang Xu, Xu Wei, you song *, application of microbial transformation in pharmacy. Journal of Shenyang Pharmaceutical University, 2006 (07): p.477-482

10. Guan Hong, Yang Li, Li Hongyan, Sun Yan, Wang Xu, you song *, Aspergillus sp