Guo Weilong

Guo Weilong

Guo Weilong, male, graduated from Tsinghua University, doctor, associate professor of China Agricultural University.

Character experience

Educational experience

2005.9-2009.7 Beijing University of Posts and Telecommunications

2009.9-2014.7 doctor of Tsinghua University

2012.10-2013.10 UCLA public training

2014.7-2016.6 post doctor of Peking University

work experience

2016.6-2017.12 lecturer of China Agricultural University

From January 2018 to now, associate professor of China Agricultural University

Teaching work

17. Lecture of plant genomics in spring semester of 18

Lecture of crop bioinformatics in autumn of 18

Research direction

Wheat genomics, bioinformatics and epigenetics.

In this study, wheat was taken as the research object, and a series of original researches were carried out by means of bioinformatics, genomics and epigenetics. At present, the main research directions include three aspects: (1) combining wheat multi omics data, using bioinformatics analysis tools to integrate genome, transcriptome and methylome data, answering the questions of wheat polyploid evolution, gene interaction network, epigenetic regulation and so on; (2) designing and developing bioinformatics tools according to the complex genomic characteristics of wheat In order to improve the efficiency of wheat multi omics research, informatics computing tools or data visualization platform should be built; (3) new bioinformatics research methods should be designed for polyploid evolution, complex regulatory networks, DNA methylation and other research problems by combining algorithms and statistics.

Papers and works

10.WeilongGuo#,PingZhu,MatteoPellegrini,MichaelZhang,XiangfengWang,ZhongfuNi.(2017)CGmapToolsimprovestheprecisionofhetero-zygousSNVcallsandsupportsallele-specificmethylationdetectionandvisualizationinbisulfite-sequencingdata,Bioinformatics,btx595.(#correspondingauthor)

9.ShenoyTR,BoysenG,WangMY,XuQZ,GuoW,KohFM,WangC,ZhangLZ,WangY,GilV,AzizS,ChristovaR,RodriguesDN,CrespoM,RescignoP,TunariuN,RiisnaesR,ZafeiriouZ,FlohrP,YuanW,KnightE,SwainA,Ramalho-SantosM,XuDY,deBonoJ,WuH.(2017)CHD1losssensitizesprostatecancertoDNAdamagingtherapybypromotingerror-pronedouble-strandbreakrepair,AnnalsofOncology,April.

8.WeilongGuo#,MichaelZhang,HongWu#.(2016)Mammaliannon-CGmethylationsareconservedandcell-typespecificandmayhavebeeninvolvedintheevolutionoftransposonelements,ScientificReports,6:32207.(#correspondingauthors)

7.QingyingMeng,ZheYing,EmilyNoble,YuqiZhao,RahulAgrawal,AndrewMikhail,YumeiZhuang,EthikaTyagi,QingZhang,Jae-HyungLee,MarcoMorselli,LuzOrozco,WeilongGuo, TinaM.Kilts ,JunZhu,BinZhang,MatteoPellegrini,XinshuXiao, MarianF.Young ,FernandoGomez-Pinilla,XiaYang.(2016)SystemsNutrigenomicsRevealsBrainGeneNetworksLinkingMetabolicandBrainDisorders,EBioMedicine, 2016May(7):157-66.

6.MarcusRuscetti, EmanL.Dadashian ,WeilongGuo,BillQuach, DavidJ.Mulholland , JuwW.Park , LinhM.Tran ,NaokoKobayashi,DaniellaBianchi-Frias, PeterS.Nelson ,YiXing,andHongWu.(2015)HDACInhibitionImpedesHMGA2-controlledEpithelial-MesenchymalPlasticityandSuppressesMetastatic,Castration-ResistantProstateCancer,Oncogene,(August),1-15.

5.LuzDOrozco,MarcoMorselli,LiudmillaRubbi,WeilongGuo,JamesGo,HuwenboShi,DavidLopez,NicholasAFurlotte,BrianJBennett,CharlesRFarber,AnatoleGhazalpour,MichaelQZhang,RenataBahous,RimaRozen,AldonsJLusis,MatteoPellegrini.(2015)Epigenome-wideassociationoflivermethylationpatternsandcomplexmetabolictraitsinmice,CellMetabolism,21(6):905-917.

4.YunLi, JasonA.Chen , ReneeL.Sears ,FuyingGao, EricD.Klein ,AnnaKarydas, MichaelD.Geschwind , HowardJ.Rosen , AdamL.Boxer ,WeilongGuo,MatteoPellegrini,SteveHorvath, BruceL.Miller , DanielH.Geschwind ,GiovanniCoppol.(2014).AnEpigeneticSignatureinPeripheralBloodAssociatedwiththeHaplotypeon17q21.31,aRiskFactorforNeurodegenerativeTauopathy,PLoSGenetics,10(3).

3.WeilongGuo,Wen-YuChung,MinpingQian,MatteoPellegrini, MichaelQ.Zhang .(2014).Characterizingthestrand-specificdistributionofnon-CpGmethylationinhumanpluripotentcells,NucleicAcidsResearch,42(5):3009-3016.

2.WeilongGuo,PetkoFiziev,WeihongYan,ShawnCokus,XueguangSun,MichaelQZhang,Pao-YangChen,MatteoPellegrini.(2