Huang Minglong

Huang Minglong

Huang Minglong (1898-1979) was born in Yangzhou, Jiangsu Province. Organic chemist, founder of steroid medicine industry in China. He was a researcher of Shanghai Institute of organic chemistry, Chinese Academy of Sciences.

In 1924, he received his Ph.D. from Berlin University. In 1955, he was elected member of the academic department of the Chinese Academy of Sciences. He died on July 1, 1979.

Huang Ming long devoted his whole life to the research of organic chemistry, especially the synthesis of steroids, and made outstanding contributions to the development of organic chemistry, the establishment of steroidal drug industry and the cultivation of scientific and technological talents.

Life of the characters

Born on July 3, 1898 in Yangzhou, Jiangsu Province.

From 1916 to 1920, he studied in Zhejiang Medical College (now known as Medical College of Zhejiang University).

From 1920 to 1922, he studied in the University of Zurich, Switzerland.

From 1922 to 1924, he studied at the University of Berlin in Germany and obtained his PhD.

From 1924 to 1928, he served as the director of the laboratory of Zhejiang Provincial Institute of health, director of the Department of technology and chemistry of the Department of health, and professor of pharmacy of Zhejiang Medical College.

From 1928 to 1934, he was professor and director of Pharmacy Department of Zhejiang Provincial College of medicine.

From 1935 to 1938, he was a visiting professor in the Institute of chemistry, University of weitzburg, Germany.

In 1940, he was a professor at the Institute of synthetic steroids in Germany.

From 1940 to 1945, he was a researcher in Institute of chemistry, Academia Sinica (Kunming) and a professor in southwest United University.

From 1945 to 1949, he was a visiting professor in the Department of chemistry, Harvard University.

From 1949 to 1952, he was a researcher in Merck pharmaceutical company.

In October 1952, with his wife, daughter and some instruments, after many twists and turns and risks, he finally left the United States, bypassed Europe and returned to his motherland.

From 1952 to 1956, he was director and researcher of Department of chemistry, Academy of Military Medical Sciences.

In 1955, he was elected member of the Department of mathematical chemistry, Chinese Academy of Sciences.

In 1958, under his leadership, he studied the advanced method of synthesizing cortisone with domestic diosgenin as raw material, and achieved success. He assisted the industrial sector to put into production soon, so that the project originally scheduled for the third five year plan by the state was realized several years ahead of schedule. China's steroid hormone drugs also jumped from import to export.

In October 1959, cortisone acetate won the National Invention Award. At the same time, he also taught steroidal chemistry in person and trained a group of professionals who were familiar with steroidal chemistry.

In 1965, the family planning group of the State Science and Technology Commission was established, with Huang Minglong as the deputy leader.

From 1956 to 1979, he was a research fellow, director of the academic committee and honorary director of Shanghai Institute of organic chemistry, Chinese Academy of Sciences.

He died in Shanghai on July 1, 1979.

Main achievements

Achievements in scientific research

In his early years, he studied the effective components of Corydalis yanhusuo and asarum. After studying the steroidal chemistry, we found the diene phenol reaction of steroids and applied it to the study of stereochemistry of shandaonian and its analogues. It is found that the four analogues of shandaonian can be changed in a circle under the action of acid and alkali, and the relative configuration can be deduced, which provides a theoretical basis for solving the absolute configuration and total synthesis of shandaonian and its analogues at home and abroad. The modified kaixiner Wolff reduction method, known as "Huang Minglong improved reduction method", has been included in the organic chemistry textbooks of various countries. Cortisone was synthesized from diosgenin in seven steps and put into production soon. It is the founder of steroid medicine industry in China. Megestrol, the first oral contraceptive in China, and several other major steroid family planning drugs were developed.

Reduction reaction of Huang Minglong

In 1945, he made a breakthrough in the research of Cassina wallf reduction method in the United States. It is internationally known as Huang Ming Long reduction method. Huang Ming Long's reduction method is

Among thousands of reactions of organic chemical names, the only one named by Chinese people (1 / 3 exactly)! it

Based on Wolff Kishner reduction method, Huang Minglong improved the reaction conditions. First, the aqueous solutions of aldehyde, ketone, sodium hydroxide and hydrazine were heated together with a water-soluble solvent (such as diethylene glycol and triethylene glycol) with high boiling point to make aldehyde and ketone turn into hydrazone, and then the excess water and unreacted hydrazine were evaporated. When the decomposition temperature of hydrazone reached about 200 ℃, the reflux continued for 3-4 hours In this way, the anhydrous hydrazine in Wolff Kishner method can not be used, the reaction can be carried out under normal pressure, and the reaction time can be shortened, and the reaction yield can be increased (up to 90%).

other

He led the research on the synthesis of cortisone by seven steps and assisted the industrial sector to put it into production. He led the research and development of megestrol and other family planning drugs and made great contributions to the establishment of steroid drug industry. More than 100 papers have been published on steroid synthesis and steroid reaction.

1 (a) Huang Ming long, relationship between steroidal conformation and chemical reaction (I-IV) chemical bulletin 1955:449-452532-535660-663724-727.

(b) Huang Ming long, relationship between infrared spectrum and molecular structure of organic compounds. Science Press, 1958.

(c) Huang Weiheng, Huang Minglong, application of NMR in organic chemistry. Science Bulletin, 1960341-345.

(d) Huang Ming long, application of polarimetry in organic chemistry. Science Press, 1963

2 (a) Huang Ming long, Tao zheng'e, elimination reaction in unsaturated cholic acids, Acta chemica Sinica, 1956,22:581584.

(b) Huang Wenhong, Huang Minglong, a preliminary study on 1,6-elimination reaction, Acta chemica Sinica, 1958,24:431-435.

3 (a) Huang Ming long, Zhou Wei Shan. Stereochemistry of shandaonian and its analogues. Acta Pharma Sinica Sinica, 1956, 4:73-95.

(b) Huang Ming long, Zhou Wei Shan. Studies on the first class of shandaonian. VI. the relative configuration of metamorphic shandaonian. Acta chemica Sinica, 1956, 22:493-506.

(c) Huang Ming long, Zhou Wei Shan. Studies on the first class of shandaonian. VII. The relative configuration of metamorphic shandaonian. Acta chemica Sinica, 1956, 22:578-580.

(d) Huang Ming long, Zhou Wei Shan. Studies on the first class of shandaonian. Ⅷ. The relative configuration of metamorphic shandaonian. Acta chemica Sinica, 1958, 24:210-216.

(e) Zhou Weishan, Huang Minglong. Studies on a class of compounds of shandaonian. IX. shift reaction of diene amine benzene. Acta chemica Sinica, 1959,25:327-329

Huang Ming long. How to advance to science, Shanghai Union of science and technology, 1956, 16:1-3.

5. Huang Ming long, Cai Zu Yun, Wang Zhi Qin, et al. Synthesis of paranephrone acetate, Acta chemica Sinica, 1959,25:295-301.

6 Huang Ming long, Wu Zhao Hua, Jin Shan Wei, et al. Synthesis of paracetamol acetate. Acta chemica Sinica, 1959,25:301-307.

7. Huang Ming long, Cai Zu Yun, Wang Zhi Qin, synthesis of B α - methyl - paracetamol acetate, Acta chemica Sinica, 1959,25:308-311.

8 (a) Chen Yuqun, Huang Minglong. Synthesis of B α - methyl-17 α - acetoxyprogesterone, Acta Chem Sinica, 1959,25:424-426.

(b) Chen Yuqun, Huang Minglong, synthesis of △′ - 16-methylene-11-keto-17 α - hydroxy paranephrone, Acta Pharma Sinica Sinica, 1964, 11:587.

9. Xu Jinwen, Wang Zhiqin, Huang Minglong. Synthesis of △ 6-6-methylparacephrenone acetate.

In 1982, he won the second prize of National Natural Science Award.

Honorary recognition

In 1955, he was elected member of the academic department of the Chinese Academy of Sciences.

Social service

He has successively served as director of the Department of chemistry of the Chinese Academy of Medical Sciences, researcher of the Institute of organic chemistry of the Chinese Academy of Sciences, member (academician) of the Department of mathematical and physical chemistry of the Chinese Academy of Sciences, and vice chairman of the Chinese Pharmaceutical Association.

He is a deputy to the third National People's Congress and a member of the second, third and Fifth National Committee of the Chinese people's Political Consultative Conference.

Character evaluation

Huang Minglong has been fighting selflessly in the front line of scientific research for decades, making great contributions to China's socialist construction and cultivating a large number of scientific research backbones.