Guo Wenli

Guo Wenli

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Guo Wenli, female, doctor, is a teacher of Fisheries College of Henan Normal University.

Research direction

1. Toxic effect and mechanism of environmental pollutants and exogenous factors on fish;

2. Research and development of rapid detection products in aquaculture: detect water quality, diseases and pesticide residues by enzyme immunoassay, colloidal gold and other methods.

academic achievements

Participating in the project

1. Mechanism of compound toxic effect of organophosphorus pesticide chlorpyrifos and cadmium on hepatocytes 21377159 general project of NSFC 2014.01-2017.12905

2. Reveal the molecular mechanism of nano silver hepatotoxicity based on Metallomics 21407169 youth fund of NSFC 2015.01-2017.12262

3. Research on the mechanism of nano silver influencing the differentiation and maturation of erythroid precursor cells by changing the stability of genetic information 21407172 youth fund of NSFC 2015.01-2017.12282

4. Regulatory mechanism and toxicity of rare earth oxide nanomaterials on DNA methylation and hydroxymethylation 21577165 general project of NSFC 2016.01-2019.12662

5. Preliminary study on the mechanism of fish hepatotoxicity induced by combined exposure of PCBs and cadmium

6. Development of ammonia nitrogen detection reagent for aquaculture water quality 162102210071 tackling key scientific and technological problems of Henan Provincial Department of science and technology 2016.01-2017.12101

publish one’s thesis

1.Guo,W.;Zhang,S.;Chen,Y.;Zhang,D.;Yuan,L.;Cong,H.;Liu,S.Animportantroleofthehepcidin-ferroportinsignalinginaffectingtumo rgrowthandmetastasis.ActabiochimicaetbiophysicaSinica2015 .

2.Guo,W.;Zhang,S.;Liu,S.Establishmentofanovelorthotopicmodelofbreastcance rmetastasistothelung.Oncologyreports2015 ,33,2992-8.

3.Guo,W.;Zhang,J.;Li,W.;Xu,M.;Liu,S.Disruptionofironhomeostasisandresultanthealtheffectsuponexposuretovariousenvironmentalp ollutants:Acriticalreview.Journalofenvironmentalsciences (China)2015,34,155-64.

4.Sun,L.*;Guo,W.*;Yin,C.;Zhang,S.;Qu,G.;Hou,Y.;Rong,H.;Ji,H.;Liu,S.Hepcidindeficiencyunderminesboneload-bearingcapacitythrough inducingironoverload.Gene2014 ,543,161-5.(*co-firstauthor)

5.He,W.;Guo,W.;Qian,Y.;Zhang,S.;Ren,D.;Liu,S.Synergistichepatotoxicitybycadmiumandchl orpyrifos:disorderedhepaticlipidhomeostasis.Molecularmedicinereports2015 ,12,303-8.

6.Qian,Y.;Zhang,S.;Guo,W.;Ma,J.;Chen,Y.;Wang,L.;Zhao,M.;Liu,S.Polychlorinatedbiphenyls(PCBs)inhibithepcidinexpressionthroughanestrogen-likeeffectassociatedwithdisorderedsys temicironhomeostasis.Chemicalresearchintoxicology2015 ,28,629-40.

7.Zhang,S.;Chen,Y.;Guo,W.;Yuan,L.;Zhang,D.;Xu,Y.;Nemeth,E.;Ganz,T.;Liu,S.Disorderedhepcidin-ferroportinsignalingpromot esbreastcancergrowth.Cellularsignalling2014 ,26,2539-50.

8.Zhang,M.;Liu,J.;Guo,W.;Liu,X.;Liu,S.;Yin,H.IcariinregulatessystemicironmetabolismbyincreasinghepatichepcidinexpressionthroughStat3andSmad1/5/8 signaling.Internationaljournalofmolecularmedicine2016 ,37,1379-88.

9.Sun,L.;Zhang,S.;Guo,W.;He,W.;Qian,Y.;Qu,G.;Ji,H.;Rong,H.;Liu,S.Sublethalexposureoforganophosphatepesticidechlorpyrifosalterscellularironmetabolisminhepat ocytesandmacrophages.Internationaljournalofmolecularmedicine2014 ,34,1395-400.

10.Chen,Y.;Zhang,S.;Wang,X.;Guo,W.;Wang,L.;Zhang,D.;Yuan,L.;Zhang,Z.;Xu,Y.;Liu,S.Disorderedsignalinggoverningferroportintranscriptionfavo rsbreastcancergrowth.Cellularsignalling2015 ,27,168-76.

11.Sun,L.;Wang,L.;Wang,Z.;He,W.;Zhang,S.;Guo,W.;Qian,Y.;Ji,H.;Rong,H.;Liu,S.Cadmiumdepletescellularironavailabilitythroughenhancingferroportintranslationviai ronresponsiveelement.Molecularmedicinereports2015 ,11,3129-33.