Zhang Hong

Zhang Hong

Zhang Hong, male, majored in cell biophysics, is currently a researcher in Institute of Biophysics, Chinese Academy of Sciences. In May 2020, it won the second national innovation competition award.

Biography of characters

1987-1991 bachelor's degree, Anhui University; 1991-1994 master's degree, Department of medicine, Peking University; 1994-2001 doctor's degree, Einstein School of medicine; 2001-2004 postdoctoral degree, cancer center, Massachusetts General Hospital; 2004-2009 researcher, Beijing Institute of life sciences; 2009-2012 senior researcher, Beijing Institute of life sciences; 2012 present Institute of biophysics, Chinese Academy of Sciences Researcher

Research direction

Research direction: mechanism and regulation of autophagy in multicellular organisms

Character honor

In 2018, Zhenxi bioscientist award in 2016, ten thousand talents plan in 2014, young and middle-aged leading talents in scientific and technological innovation in 2013, Tan Jiazhen Life Science Innovation Award in 2012, National Science Fund for Distinguished Young Scholars in 2012, Howard Hughes Institute of Medicine International Young Scientists award in 2006, Lilly Asia outstanding scientific research achievement award in 2020, second prize of National Natural Science Award in 2019, 2020 In May, he won the second national innovation competition award.

Character works

1.Zhang,G.M.,Wang,Z.,Du,Z.,and

Zhang,H

.(2018)mTORregulatesphaseseparationofPGLgranulestomodulatetheirautophagicdegradation.

Cell

174,1492-1506. 2.Zhao,G.Y.,Chen,Y.,Miao,G.Y.,Zhao,H.Y.,Qu,W.Y.,Li,D.F.,Wang,Z.,Liu,N.,Li,L.,Chen,S.,Liu,P.S.,Feng,D.,and

Zhang,H.

(2017)TheER-localizedtransmembraneproteinVMP1regulatesSERCAactivitytocontrolER-isolationmembranecontactsforautophagosomeformation.

MolecularCell

67,974-989.(Coverstory) 3.Wang,Z.,Miao,G.Y.,Xue,X.,Guo,X.Y.,Yuan,C.Z.,Wang,Z.Y.,Zhang,G.M.,Feng,D.,Hu,J.J.,and

Zhang,H.

(2016)TheVicisyndromeproteinEPG5isaRab7effectorthatdeterminesthefusionspecificityofautophagosomeswithlateendosomes/lysosomes.

MolecularCell

63,781-795. 4.Wu,F.,Watanabe,Y.,Guo,X.Y.,Qi,X.,Wang,P.,Zhao,H.Y.,Wang,Z.,Fujioka,Y.,Zhang,H.,Ren,J.Q.,Fang,T.C.,Shen,Y.X.,Feng,W.,Hu,J.J.,Noda,N.N.and

Zhang,H.

(2015)StructuralbasisofthedifferentialfunctionofthetwoC.elegansAtg8homologs,LGG-1andLGG-2,inautophagy.

MolecularCell

60,914-929. 5.Zhao,G.Y.,Sun,L.,Mia,G.Y.,Ji,C.C.,Zhao,H.Y.,Sun,H.Y.,Miao,L.,Yoshii,S.R.,Mizushima,N.,WangX.Q.,and

Zhang,H.

(2015)TheautophagygeneWdr45/Wipi4regulateslearningandmemoryfunctionandaxonalhomeostasis.

Autophagy

11,881-890. 6.Guo,B.,Liang,Q.Q.,Li,L.,Hu,Z.,Wu,F.,Zhang,P.P.,Ma,Y.F.,Zhao,B.,Kovács,A.L.,Zhang,Z.Y.,Feng,D.,Chen,S.,and

Zhang,H.

(2014)O-GlcNAc-modificationofSNAP-29regulatesautophagosomematuration.

NatureCellBiology

16,1215-1226. 7.Li,S.H.,Yang,P.G.,Tian,E,and

Zhang,H.

(2013)ArgininemethylationmodulatesautophagicdegradationofPGLgranulesinC.elegans.

MolecularCell

52,421-433. 8.Zhao,H.Y.,Zhao,G.Y.,Wang,X.W.,Xu,L.J.,Miao,L.,Feng,D.,Chen,Q.,Kovács,A.L.Fan,D.S.,and

Zhang,H.

(2013)MicedeficientinEpg5exhibitselectiveneuronalvulnerabilitytodegeneration.

TheJournalofCellBiology

200,731-741. 9.Lu,Q.,Yang,P.G.,Huang,X.X.,Hu,W.Q.,Guo,B.,Wu,F.,Lin,L.,Kovács,A.L.,Yu,L.and

Zhang,H.

(2011)TheWD40repeatPtdIns(3)P-bindingproteinEPG-6regulatesprogressionofomegasomestoautophagosomes.

DevelopmentalCell

21,343-357. 10.Tian,Y.,Li,Z.P.,Hu,W.Q.,Ren,H.Y.,Tian,E,Zhao,Y.,Lu,Q.,Huang,X.X.,Yang,P.G.,Li,X.,Wang,X.C.,Kovács,A.L.,Yu,L.and

Zhang,H.

(2010)C.elegansscreenidentifiesautophagygenesspecifictomulticellularorganisms.

Cell

141,1042-1055. 11.Zhang,Y.X.,Yan,L.B.,Zhou,Z.,Yang,P.G.,TianE,Zhang,K.,Zhao,Y.,Li,Z.P.,Song,B.,Han,J.H.,Miao,L.,and

Zhang,H.

(2009)SEPA-1mediatesthespecificrecognitionanddegradationofPgranulecomponentsbyautophagyinC.elegans.

Cell

136,308-321.