Wu Ying

Wu Ying

Wu Ying: researcher, State Key Laboratory of brain and cognitive science, Institute of Biophysics, Chinese Academy of Sciences. He is the leader of innovation research group and senior consultant researcher of Institute of Biophysics, Chinese Academy of Sciences.

The main research direction is to reveal the molecular mechanism of gene regulation involved in neurodevelopment and neurodegenerative diseases.

Learning experience

1980-1986, doctor of tumor biology, Stanford University, USA, 1986-1991, postdoctoral candidate, Department of Biochemistry and molecular biology, Harvard University, 1991-1994

work experience

Since 1994, he has been assistant professor in Department of Pediatrics and Department of molecular biology and pharmacology of University of Washington, and doctoral supervisor in molecular genetics, molecular cell biology, developmental biology and other disciplines. Since 1998, he has also been a professor in Shanghai Medical University. Since 2001, he has participated in the teaching of postgraduate course of molecular biology in Shanghai Institute of life sciences, Chinese Academy of Sciences. Later, he was promoted to associate professor and obtained tenure. 2003-2005, Vanderberg, USA Prof. Charles luismix, School of medicine, Northwestern University, USA, 2005-2008 - now senior consultant, Institute of Biophysics, Chinese Academy of Sciences

research field

Research direction

Professor Wu Ying's research group mainly studies the molecular mechanisms involved in gene regulation of neurodevelopment and neuropathy

Specific research contents

1) Molecular mechanism of RNA regulation of 2) cell migration

Hold a post

He reviewed 15 journals including science, nature, cell, MCB, PNAs, and other journals. He was also awarded the National Institutes of health, the Alzheimer's foundation, the Medical Research Council of Canada, and the telethon foundation of Italy. He participated in biochemistry teaching at Harvard University, nucleic acid and protein, cell biology Doctoral Course Teaching at the University of Washington, and made academic reports at Cambridge, Harvard, University of Pennsylvania, Brown University, etc. he is currently professor of Northwestern University, Professor of Yangtze River, Tsinghua University, and researcher of Institute of Biophysics, Chinese Academy of Sciences. Wu Ying is famous for studying the molecular biology of RNA splicing. He was awarded the category B of "National Fund for Distinguished Young Scholars" by National Natural Science Foundation of China.

academic achievements

Papers published in cell, nature, science, MCB, J. neuroscience, JBC. He has been supported by the American Leukemia Society for 12 consecutive years (from postdoctoral, special researcher to Scholar Award)

publish one’s thesis

GöhrigA,DetjenKM,HilfenhausG,KörnerJ,ArsenicR,WelzelM,SchmuckR,BahraM,WuJY,WiedenmannB,FischerC(2014).TheAxonGuidanceFactorSlit2inhibitsPancreaticCancerMetastasisandCellMovementalongNeurites.

CancerRes

.74(5):1529-40 LiY,YangM,HuangZ,ChenX,MaloneyM,ZhuL,LiuJ,YangY,DuS,JiangX,WuJY.(2014) AxonQuant:amicrofluidicchamberculture-coupledalgorithmthatallowshigh-throughputquantificationofaxonaldamage.

NeuroSignalsFeb

28. RNAandCancer.WuJY (ed.)ISBN978-3-642-316586;LibraryofCongressControlNumber2012946188(Springer,2013) POST-TRANSCRIPTIONALGENEREGULATION-RNAPR OCESSINGINEUKARYOTES.WuJY (ed.)ISBN978-3527322022(Wiley-Blackwell,2013) BigioEH,WuJY,DengHX,Bit-IvanEN,MaoQ,GantiR,PetersonM,SiddiqueN,GeulaC,SiddiqueT, MesulamM.(2013)InclusionsinfrontotemporallobardegenerationwithTDP-43proteinopathy(FTLD-TDP)andamyotrophiclateralsclerosis(ALS),butnotFTLDwithFUSproteinopathy(FTLD-FUS),havepropertiesofamyloid.

ActaNeuropathol

.125(3):463-5. XuM,ZhuL,LiuJ,YangY,WuJY,WangC(2013)Characterizationofβ-domainsinC-terminalfragmentsofTDP-43byscanningtunnelingmicroscopy.

JStructBiol.

181(1):11-6. ChenQ,SunX,ZhouXH,LiuJH,WuJ,ZhangY,WangJH(2013)N-terminalhorseshoeconformationofDCCisfunctionallyrequiredforaxonguidanceandmightbesharedbyotherneuralreceptors.J

CellSci.

126:186-95. ZhuK,ChenXP,LiuJH,YeHh,ZhuL,WuJY(2013)AMPKinteractswithDSCAMandplaysanimportantroleinNetrin-1inducedneuriteoutgrowth.

ProteinCell

4(2):155–161. ChenY,YangM,DengJ,ChenX,YeY,ZhuL,LiuJ,YeH,ShenY,LiY,RaoEJ,FushimiK,ZhouX,BigioEH,MesulamM,WuJY.(2011)ExpressionofhumanFUSproteininDrosophilaleadstoprogressiveneurodegeneration.

ProteinCell

2(6):477–486. RayP,KarA,FushimiK,HavliogluN,ChenX,WuJY(2011)PSFSuppressesTauExon10InclusionbyInteractingwithaStem-LoopStructureDownstreamofExon10.J

MolNeurosci

.45(3):453-66. XuY,YeH,ShenY,XuQ,ZhuL,LiuJ,WuJY.(2011)Dscammutationleadstohydrocephalusandde creasedmotorfunction.ProteinCell .2(8):647-55. YuB,FeyP,Kestin-PilcherKE,FedorovA,PrakashA,ChisholmRL,WuJY.(2011)Spl iceosomalgenesintheD.discoideumgenome :aco mparisonwiththoseinH.sapiens ,D.melanogaster,A. thalianaandS.cerevisiae.ProteinCell .2(5):395-409. GuoW, ChenY,ZhouX,KarA,RayP,ChenX,RaoEJ,YangM,YeH,ZhuL,LiuJ