Wang Zhao
Wang Zhao, Professor, School of life sciences, Tsinghua University, Professor, doctoral supervisor, School of medicine, Tsinghua University.
Character experience
1978-1983, Bachelor of medicine, Department of medicine, Henan University of traditional Chinese medicine. 1984-1987, School of basic medicine, Beijing University of traditional Chinese medicine, master of medicine. 1990-1993, master of pharmacy, School of pharmacy, Okayama University, Japan. 1993-1996, doctor of pharmacy, School of pharmacy, Okayama University, Japan. 1996-1998, assistant professor, School of medicine, Okayama University, Japan. 1998 - associate professor, professor and double employed professor of School of life sciences, Tsinghua University. 2004 - Professor, School of medicine, Tsinghua University. 2006-2007, visiting professor, Mount Sinai School of medicine, New York University, USA.
Research direction
Molecular cellular pharmacology and toxicology: pharmacology and toxicology of traditional Chinese medicine, neuropharmacology, tumor pharmacology, bone metabolism and drug intervention; aging mechanism and drug intervention research: especially brain aging and drug on neurodegenerative diseases and other aging related diseases; research and development of natural drugs and functional health care products.
Main contributions
1·JingDu,JunleiChang,SongxiGuo,QingZhang,ZhaoWang*.ApoE4ReducesthedegradingenzymeIDEbyActivatingtheNMDAReceptorinExpressiono fAHippocampalNeurons.NeuroscienceLetters .(2009)(inpress)
2·JingDu,BingSun,KuiChen,LiFan, ZhaoWang*.AntagonistofPeroxisomeProliferator-activatedReceptorInducesCerebellarAmyloid-LevelsandMotorDysfunctioninAPP/PS1 TransgenicMice.BiochemBiophResCo .384(3):357-361(2009)
3·Zong-ChunYi,Yan-ZeLiu,Hai-XiaLi,ZhaoWang*.ChebulinicacidandtellimagrandinIinhibitDNAstrandbreaksbyhydroquinone/Cu(II)andH2O2/Cu(II), butpotentiateDNAstrandbreaksbyH2O2/Fe(II).ToxicologyinVitro.23(4)667–673(2009)
4·JingDu,BingSun,KuiChen,LangZhang,ShuboLiu,QingquanGu,LiFan,NanmingZhao,ZhaoWang*.MetabolitesofNeuronsPlayEssentialRoleinPathogenesisofAlzheimer' sDisease.PLoSONE .4(5):e5530(2009)
5·JingDu,LangZhang,ShuboLiu,ChiZhang,XiuqingHuang,JianLi, NanmingTranscriptionallyRegulatestheExpressionofZhao,ZhaoWang*.PPARInsulindegradingEn zymeinPrimaryNeurons.BiochemBiophResCo .383(4):485-490(2009)·
6·MinFu,RuxinLi,LiFan,GuoweiHe,KentLThornburg, ZhaoWang*:SarcoplasmicReticulumCa2+ReleaseChannelRyanodineReceptor(RyR2)PlaysaCrucialRoleinAconitine- inducedArrhythmias.BiochemicalPharmacology .75(11)2147-2156(2008)
7·MingchaoXIE,ChaoAI,ShangfengLIU,ShixinTAO, ZhaoWANG*CloningandcharacterizationofchickenSPATA4geneandanalysisofi tsspecificexpression.MolecularandCellularBiochemistry .306(1-2):79-85(2007)
8·MinFu,MengWu,JifengWang,YanjiangQiao, ZhaoWang*:DisruptionoftheIntracellularCa2+HomeostasisintheCardiacExcitation-ContractionCouplingisaCrucialMechanismofArrhythmicToxicityinAconitine-i nducedCardiomyocytes.BiochemBiophResCo .354(4):929-936(2007)
9·LiuHai-Luo,LiuShang-Feng,GeYe-Jing,LiuJing,WangXiao-Yan,XieLi-Ping,ZhangRong-Qing, WangZhao*:IdentificationandcharacterizationofabiomineralizationrelatedgenePFMG1highlyexpressedinthema ntleofpinctadafucata.Biochemistry .46(3):844-851(2007)
10·Zong-ChunYi,ZhaoWANG*,Hai-XiaLi,YanYin,Feng-YuanZhuang, andYu- BoFan:TellimagrandinIenhancesgapjunctionalcommunicationandattenuatesthetumorphenotypeofhumancervicalcarcinomaHeLacellsinvitro.CancerLetters.242 (1) 77-87 (2006)
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